Presence of methyl paraben in anti-diabetic herbal preparations
نویسندگان
چکیده
Plant-based hypoglycemic therapeutics have been increasing in consumption due to the escalation of type 2 diabetes and its related complications. However, safety preparations is little understood. Parabens (alkyl esters p-hydroxybenzoic acid) are widely used as preservatives these pharmaceuticals. presence methylparaben formulations raises anxiety potential endocrine disruption functions. Endocrine could lead undesirable health abnormalities carcinogenic, estrogenic, adverse reproductive effects. The present investigation directs toward estimating some anti-diabetic herbal using UV- Vis spectrophotometric method abiding by International Conference on Harmonization (ICH) guidelines for validation. analytical wavelength methanol was determined found at 256.5 nm. obeys Beer’s law range has a good coefficient determination (r2= 0.9881). limit detection (LOD) quantification (LOQ) were 0.19 ppm 0.57 ppm, respectively. Recoveries 91.3-98.8% analyte-free plant matrix 91-105.8 % diluent. variation (CV%) varied between 0.005- 0.268% different standards. Results forty-eight showed detected thirty-four samples 13.12 – 325.13 mg/day with mean exposure value 78.25 mg/day. none raise concerns about (the ceiling paraben 420 mg/day). More required determine, whether drugs safe consume terms methylparaben. J. Asiat. Soc. Bangladesh, Sci. 48(1-2): 41-52, June-December 2022
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ژورنال
عنوان ژورنال: Journal of the Asiatic Society of Bangladesh. Science
سال: 2023
ISSN: ['2408-8676', '1016-6947']
DOI: https://doi.org/10.3329/jasbs.v48i1-2.64513